CD200 in Human Breast Cancer
Researchers: Co-Principal Investigators: D.A. Clark & B. Dhesy
Co-Investigator: J. Ramsay
Status: Funded 2011
Open to accrual
It has been recognized that an established tumor is able to shut down immune rejection cells so they can’t work. A molecule called CD200 appears to be very important in this shut down process. CD200 is expressed on stem cells. All tissues in the body develop from stem cells. When a genetic change occurs in a stem cell, it may become malignant and give rise to a collection of more developed cells recognized as a cancer, and many of these cells do not express CD200. However, as long as CD200 is present, the stem cell can evade rejection. Chemotherapy is most effective when aided by an immune response, but killing the last cell requires eradicating cancer stem cells. Over time, more and more genetic changes in stem cells enable the tumor to metastasize to different organs, and resist chemotherapy. In this project, tumor tissues removed at surgery are stained for CD200+ cells, to see if tumors with a large percentage of these cells are more aggressive. CD200+ cells can also protect CD200- tumor cells from rejection by releasing CD200 in soluble form into surrounding tissues and the blood stream. Investigators expect to find more CD200 in the blood when there are more CD200+ cells in the tumor. Eventually, we hope to predict which women will benefit most from a new monoclonal antibody to human CD200.